No insulin injections, no avoiding sugar. A daily drug can reverse diabetes symptoms in mice, opening up the possibility of a much easier way for diabetics to keep their blood sugar level within safe limits. A daily pill that restores the body’s sensitivity to insulin may make it easier to control the diabetes boom in rich nations where obesity is on the rise.
The drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which seems to contribute to cells losing their sensitivity to insulin. By hindering LMPTP, the drug reawakens insulin receptors on the surface of cells – especially in the liver – which normally absorb excess sugar from the blood when they detect insulin.
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