The fourth-seeded Federer outlasted No. 14 Roberto Bautista Agut 7-6 (5), 7-6 (4), the fifth-seeded Nadal got past Nicolas Marut 6-4, 7-6 (4), and Nishikori -- a finalist at Key Biscayne a year ago -- rallied from a break down in the final set to beat Federico Delbonis 6-3, 4-6, 6-3.
Federer is 16-1 this year, matching his career-best record at this point in a season.
"Is it the best I've ever played?" Federer said. "For me, it's hard to say yes to that question. ... Maybe on the offensive side, overall, I think I'm doing definitely a few things better than I ever have. I do feel that I have improved. The game has evolved, I had to adjust, but overall I do believe I'm probably a better player than I was 10 years ago."
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