Wigan Warriors and Warrington Wolves booked Challenge Cup quarter-final places on Sunday after 28-10 and 66-10 wins over Hull KR and Toronto respectively.
The quarter-final draw, which was also made on Sunday, sees the Wolves face the Warriors, while also pairing holders Hull with Super League leaders St Helens for a place in the semi-finals.
Hull, who are seeking a third successive Wembley triumph, will play their quarter-final on the first weekend of June at the Totally Wicked Stadium, where they lost 26-12 in the league in April.
Former St Helens captain Jon Wilkin said: "Hull FC are a big physical side who have had recent success in the cup but we'll attack that quarter-final, we can't wait."
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