Teenager Jordan Petaia will start at outside centre for Australia in Saturday's World Cup quarter-final against England in Oita.
The 19-year-old is Australia's youngest Test centre since Jason Little 30 years ago. He also becomes the first player born this century to feature in a Rugby World Cup knockout game.
Petaia moves from wing to midfield, with Reece Hodge returning after serving a three-match suspension.
Hodge was banned following his citing for a high tackle on Fiji's Peceli Yato in the Wallabies' opening World Cup fixture last month.
Other changes see half-backs Christian Lealifano and Will Genia both start, plus skipper Michael Hooper, who wins his 99th cap, and prop Allan Alaalatoa.
Full-back Kurtley Beale, meanwhile, starts after completing graduated return-to-play protocols.
Saturday's encounter at Oita Stadium is the countries' seventh World Cup meeting, with the current head-to-head standing at 3-3.
However, Australia have lost their last six games against England since beating them at Twickenham during the 2015 World Cup.
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